Interaction-induced star formation in a complete sample of 10^5 nearby star-forming galaxies

We investigate the clustering properties of a complete sample of 10^5 star-forming galaxies drawn from the SDSS DR4. On scales less than 100 kpc, the amplitude of the correlation function exhibits a strong dependence on the specific star formation rate of the galaxy. We interpret this as the signature of enhanced star formation induced by tidal interactions. We then explore how the average star formation rate in a galaxy is enhanced as the projected separation r_p between the galaxy and its companions decreases. We find that the enhancement depends strongly on r_p, but very weakly on the relative luminosity of the companions. The enhancement is also stronger in low mass galaxies than in high mass galaxies. In order to explore whether a tidal interaction is not only sufficient, but also necessary to trigger enhanced star formation in a galaxy, we compute background subtracted neighbour counts for the galaxies in our sample. The average number of close neighbours around galaxies with low to average values of SFR/M* is close to zero. At the highest specific star formation rates, however, more than 40% of the galaxies in our sample have a companion within a projected radius of 100 kpc. Visual inspection of the highest SFR/M* galaxies without companions reveals that more than 50% of these are clear interacting or merging systems. We conclude that tidal interactions are the dominant trigger of enhanced star formation in the most strongly star-forming systems. Finally, we find clear evidence that tidal interactions not only lead to enhanced star formation in galaxies, but also cause structural changes such as an increase in concentration.Comment: v1: 13 pages, 12 figures, submitted for publication in Monthly Notices; v2: 15 pages, 14 figures, accepted for publication, a new analysis (sec. 6 and figs 13 and 14) is done in order to address the effect of rich environment

Longitudinal Analysis of Memory B and T Cell Responses to Dengue Virus in a 5-Year Prospective Cohort Study in Thailand

Prior exposure to dengue virus (DENV) has a profound impact on the outcome of infection, which varies according to the interval between infections. Antibodies secreted by B cells and cytokines secreted by T cells are thought to contribute both to protective immunity against DENV and the pathogenesis of dengue disease. We analyzed peripheral blood mononuclear cells (PBMC) collected from Thai children over a 5-year prospective cohort study to define the dynamics of DENV-specific memory B and T cell responses and the impact of symptomatic or subclinical DENV infections. To measure B cell responses, PBMC were stimulated with IL-2 plus R848 and culture supernatants were tested for DENV-binding antibodies by ELISA. To measure T cell responses, PBMC were stimulated in dual-color ELISPOT assays with overlapping peptide pools of structural and non-structural proteins from the four DENV types. B cell responses were low to one or more DENV types prior to symptomatic infection and increased with reactivity to all four types after infection. Subjects who had a subclinical infection or who did not experience a DENV infection during the study period showed strong memory B cell responses to all four DENV types. T cell responses to DENV peptides demonstrated a cytokine hierarchy of IFN-γ \u3e IL-2 \u3e IFN-γ/IL-2. T cell responses were low or absent prior to secondary infections. The trends in T cell responses to DENV peptides over 3 year post-infection were highly variable, but subjects who had experienced a secondary DENV1 infection showed higher cytokine responses compared to subjects who had experienced a secondary DENV2 or subclinical infection. The longitudinal nature of our study demonstrates persistent memory B cell responses over years and a lasting but variable impact of secondary DENV infection on DENV-specific T cell responses

Interactions, star formation and AGN activity

It has long been known that galaxy interactions are associated with enhanced star formation. In a companion paper, we explored this connection by applying a variety of statistics to SDSS data. In particular, we showed that specific star formation rates of galaxies are higher if they have close neighbours. Here we apply exactly the same techniques to AGN in the survey, showing that close neighbours are not associated with any similar enhancement of nuclear activity. Star formation is enhanced in AGN with close neighbours in exactly the same way as in inactive galaxies, but the accretion rate onto the black hole, as estimated from the extinction-corrected [O III] luminosity, is not influenced by the presence or absence of companions. Previous work has shown that galaxies with more strongly accreting black holes contain more young stars in their inner regions. This leads us to conclude that star formation induced by a close companion and star formation associated with black hole accretion are distinct events. These events may be part of the same physical process, for example a merger, provided they are separated in time. In this case, accretion onto the black hole and its associated star formation would occur only after the two interacting galaxies have merged. The major caveat in this work is our assumption that the extinction-corrected [O III] luminosity is a robust indicator of the bolometric luminosity of the central black hole. It is thus important to check our results using indicators of AGN activity at other wavelengths.Comment: v1: 10 pages, 9 figures, submitted for publication in Monthly Notices; v2: accepted, minor changes in summary and reference list update

An Innovative, Prospective, Hybrid Cohort-Cluster Study Design to Characterize Dengue Virus Transmission in Multigenerational Households in Kamphaeng Phet, Thailand

Difficulties inherent in the identification of immune correlates of protection or severe disease have challenged the development and evaluation of dengue vaccines. There persist substantial gaps in knowledge about the complex effects of age and sequential dengue virus (DENV) exposures on these correlations. To address these gaps, we were conducting a novel family-based cohort-cluster study for DENV transmission in Kamphaeng Phet, Thailand. The study began in 2015 and is funded until at least 2023. As of May 2019, 2,870 individuals in 485 families were actively enrolled. The families comprise at least 1 child born into the study as a newborn, 1 other child, a parent, and a grandparent. The median age of enrolled participants is 21 years (range 0–93 years). Active surveillance is performed to detect acute dengue illnesses, and annual blood testing identifies subclinical seroconversions. Extended follow-up of this cohort will detect sequential infections and correlate antibody kinetics and sequence of infections with disease outcomes. The central goal of this prospective study is to characterize how different DENV exposure histories within multigenerational family units, from DENV-naive infants to grandparents with multiple prior DENV exposures, affect transmission, disease, and protection at the level of the individual, household, and community

VERTICO VII: Environmental quenching caused by suppression of molecular gas content and star formation efficiency in Virgo Cluster galaxies

We study how environment regulates the star formation cycle of 33 Virgo Cluster satellite galaxies on 720 parsec scales. We present the first resolved star-forming main sequence for cluster galaxies, dividing the sample based on their global HI properties and comparing to a control sample of field galaxies. HI-poor cluster galaxies have reduced star formation rate (SFR) surface densities with respect to both HI-normal cluster and field galaxies (0.5 dex), suggesting that mechanisms regulating the global HI content are responsible for quenching local star formation. We demonstrate that the observed quenching in HI-poor galaxies is caused by environmental processes such as ram pressure stripping (RPS) simultaneously reducing molecular gas surface density and star formation efficiency (SFE), compared to regions in HI-normal systems (by 0.38 and 0.22 dex, respectively). We observe systematically elevated SFRs that are driven by increased molecular gas surface densities at fixed stellar mass surface density in the outskirts of early-stage RPS galaxies, while SFE remains unchanged with respect to the field sample. We quantify how RPS and starvation affect the star formation cycle of inner and outer galaxy discs as they are processed by the cluster. We show both are effective quenching mechanisms with the key difference being that RPS acts upon the galaxy outskirts while starvation regulates the star formation cycle throughout disc, including within the truncation radius. For both processes, the quenching is caused by a simultaneous reduction in molecular gas surface densities and SFE at fixed stellar mass surface density.Comment: 17 pages, 1 table, 5 figures, accepted for publication in Ap

The 2017 Terahertz Science and Technology Roadmap

Science and technologies based on terahertz frequency electromagnetic radiation (100GHz-30THz) have developed rapidly over the last 30 years. For most of the 20th century, terahertz radiation, then referred to as sub-millimeter wave or far-infrared radiation, was mainly utilized by astronomers and some spectroscopists. Following the development of laser based terahertz time-domain spectroscopy in the 1980s and 1990s the field of THz science and technology expanded rapidly, to the extent that it now touches many areas from fundamental science to “real world” applications. For example THz radiation is being used to optimize materials for new solar cells, and may also be a key technology for the next generation of airport security scanners. While the field was emerging it was possible to keep track of all new developments, however now the field has grown so much that it is increasingly difficult to follow the diverse range of new discoveries and applications that are appearing. At this point in time, when the field of THz science and technology is moving from an emerging to a more established and interdisciplinary field, it is apt to present a roadmap to help identify the breadth and future directions of the field. The aim of this roadmap is to present a snapshot of the present state of THz science and technology in 2016, and provide an opinion on the challenges and opportunities that the future holds. To be able to achieve this aim, we have invited a group of international experts to write 17 sections that cover most of the key areas of THz Science and Technology. We hope that The 2016 Roadmap on THz Science and Technology will prove to be a useful resource by providing a wide ranging introduction to the capabilities of THz radiation for those outside or just entering the field as well as providing perspective and breadth for those who are well established. We also feel that this review should serve as a useful guide for government and funding agencies

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells

Pediatric ependymomas are highly recurrent tumors resistant to conventional chemotherapy. Telomerase, a ribonucleoprotein critical in permitting limitless replication, has been found to be critically important for the maintenance of tumor-initiating cells (TICs). These TICs are chemoresistant, repopulate the tumor from which they are identified, and are drivers of recurrence in numerous cancers. In this study, telomerase enzymatic activity was directly measured and inhibited to assess the therapeutic potential of targeting telomerase. Telomerase repeat amplification protocol (TRAP) (n = 36) and C-circle assay/telomere FISH/ATRX staining (n = 76) were performed on primary ependymomas to determine the prevalence and prognostic potential of telomerase activity or alternative lengthening of telomeres (ALT) as telomere maintenance mechanisms, respectively. Imetelstat, a phase 2 telomerase inhibitor, was used to elucidate the effect of telomerase inhibition on proliferation and tumorigenicity in established cell lines (BXD-1425EPN, R254), a primary TIC line (E520) and xenograft models of pediatric ependymoma. Over 60 % of pediatric ependymomas were found to rely on telomerase activity to maintain telomeres, while no ependymomas showed evidence of ALT. Children with telomerase-active tumors had reduced 5-year progression-free survival (29 +/- A 11 vs 64 +/- A 18 %; p = 0.03) and overall survival (58 +/- A 12 vs 83 +/- A 15 %; p = 0.05) rates compared to those with tumors lacking telomerase activity. Imetelstat inhibited proliferation and self-renewal by shortening telomeres and inducing senescence in vitro. In vivo, Imetelstat significantly reduced subcutaneous xenograft growth by 40 % (p = 0.03) and completely abolished the tumorigenicity of pediatric ependymoma TICs in an orthotopic xenograft model. Telomerase inhibition represents a promising therapeutic approach for telomerase-active pediatric ependymomas found to characterize high-risk ependymomas.Canadian Institutes of Health Research [MOP 82727]info:eu-repo/semantics/publishedVersio